Gelsolin Is Required for Macrophage Recruitment During Remyelination of the Peripheral Nervous System

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Goncalves, AF (Author) Other; Dias, NG (Author) Other; Moransard, M (Author) Other; Correia, R (Author) Other; Pereira, JA (Author) Other; Witke, W (Author) Other; Suter, U (Author) Other; Relvas, JB (Author) Other

Journal

Title: GLIA

Vol. 58

Pages: 706-715

ISSN: 0894-1491

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 31 Citations

Scopus - 31 Citations

Other information

Authenticus ID: P-003-7FN

DOI: 10.1002/glia.20956

Abstract (EN): Reorganization of the actin cytoskeleton is necessary for Schwann cell proliferation, migration and for the morphological changes associated with sorting, ensheathing and myelination of axons. Such reorganization requires regulated severing and depolymerization of actin filaments. Gelsolin is an actin filament severing protein expressed in many cell types including Schwann cells. Using Gelsolin knockout mice, we investigated the role of this protein in the myelination and remyelination of the peripheral nervous system. Our results show that although gelsolin is not necessary for developmental myelination, it is required for timely remyelination of the sciatic nerve following crush injury. Gelsolin is necessary for macrophage motility in culture, and its absence is likely to impair the recruitment of macrophages to the injury site. (C) 2009 Wiley-Liss, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10