Glycopeptide microarray for autoantibody detection in cancer

• Type: Another Publication in an International Scientific Journal
• Date: 2011

Authors

Celso Reis (Author) ICBAS; Campos, D (Author) Other; Osorio, H (Author) FMUP; Lucio Lara Santos (Author) ICBAS

Journal

Title: Expert Review of Proteomics

Vol. 8

Pages: 435-437

ISSN: 1478-9450

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-002-P4F

DOI: 10.1586/epr.11.30

Abstract (EN): Autoantibodies to cancer-associated antigens hold promise as sensitive biomarkers for cancer detection. Based on this hypothesis, and knowing that O-glycans on proteins constitute a source of possible epitopes recognized by autoantibodies, Pedersen and colleagues have generated a glycopeptide array displaying a comprehensive library of glycopeptides and glycoproteins derived from human mucins. The profiling of sera immunoreactivity of colon cancer patients allowed the identification of cancer-associated autoantibodies to various mucin (MUC)1 and MUC4 glycopeptides carrying aberrant glycosylation. This article provides evidence for the value of glycopeptides displaying cancer-associated glycans in diagnostic applications, and opens new avenues for the expansion to other protein glycoforms, as well as to further applications of such a microarray strategy for other post-translational modifications of proteins in the search for cancer biomarker.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3