Loss of Mitochondrial SDHB Expression: What is its Role in Diffuse Thyroid Lipomatosis?

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Lau, E (Author) Other; Freitas, P (Author) FMUP; Costa, J (Author) Other; Batista, R (Author) Other; Maximo, V (Author) FMUP; Coelho, R (Author) Other; Matos Lima, L (Author) Other; Eloy, C (Author) Other; Carvalho, Davide (Author) FMUP

Journal

Title: Hormone and Metabolic Research

Vol. 47

Pages: 165-167

ISSN: 0018-5043

Publisher: Thieme

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00A-7XC

DOI: 10.1055/s-0034-1398559

Abstract (EN): Diffuse lipomatosis of the thyroid gland is a very rare disease, characterized by extensive infiltration of thyroid parenchyma by mature adipose tissue, usually not accompanied by amyloid fibrils deposition. The pathophysiology of adipose tissue infiltration in the thyroid gland remains unknown. We report a clinical case of a diffuse thyroid lipomatosis, whose immunohistochemical study of succinate dehydrogenase subunit B (SDHB) revealed loss of expression of this protein in the follicular or adipose cells. We detected the presence of a recently described SDHB gene large deletion. Loss of mitochondrial SDHB expression may have a key role in understanding the pathophysiology of thyrolipomatosis, by regulating status of lipid metabolism.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3