Poorly differentiated and undifferentiated thyroid carcinomas

• Type: Another Publication in an International Scientific Journal
• Date: 2015

Authors

Eloy, C (Author) Other; Fereira, L (Author) Other; Salgado, C (Author) Other; Soares, P (Author) FMUP; Sobrinho Simoes, M (Author) FMUP

Journal

Title: Turk Patoloji Dergisi

Vol. 31

Pages: 48-59

ISSN: 1018-5615

Publisher: Turk Patoloji Dernegi

Indexing

Scopus - 19 Citations

Other information

Authenticus ID: P-00G-JZQ

DOI: 10.5146/tjpath.2015.01314

Abstract (EN): Thyroid cancer is the most common endocrine malignancy and its incidence goes on increasing worldwide. The majority of thyroid tumours comprise well-differentiated (papillary and follicular) thyroid carcinomas that usually carry an excellent prognosis, while a minority progress to poorly differentiated carcinoma (PDTC) and, ultimately, to the highly aggressive and lethal undifferentiated carcinoma (UTC). Recently, some major advances have been made on the histologic and imunohistochemical identification, as well as on the molecular characterization of PDTC and UTC. In this review we summarize the most recent immunohistochemical and molecular findings in PDTC and UTC, giving a particular emphasis to the diagnostic and prognostic meaning of the genetic alterations.

Language: English

Type (Professor's evaluation): Scientific