HURTHLE CELL AND MITOCHONDRION-RICH PAPILLARY CARCINOMAS OF THE THYROID-GLAND - AN ULTRASTRUCTURAL AND IMMUNOCYTOCHEMICAL STUDY

• Type: Article in International Scientific Journal
• Date: 1985

Authors

Sobrinho Simoes, M (Author) FMUP; NESLAND, JM (Author) Other; HOLM, R (Author) Other; SAMBADE, MC (Author) Other; JOHANNESSEN, JV (Author) Other

Journal

Title: Ultrastructural Pathology

Vol. 8

Pages: 131-142

ISSN: 0191-3123

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 64 Citations

Scopus - 54 Citations

Other information

Authenticus ID: P-001-WM6

Abstract (EN): Of 52 consecutive papillary carcinomas of the thyroid following cases were included in this study: one Hurthle cell papillary carcinoma, one papillary carcinoma with foci of Hurthle cells, and 10 cases of papillary carcinoma with abundant mitochondria (volumetric density of mitochondria ≥ 20%). All cases were studied by light microscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and immunocytochemistry. Our results showed that papillary carcinomas mainly or exclusively composed of Hurthle cells are very rare; that Hurthle cell papillary carcinomas of the thyroid share the biologic characteristics and blend insidiously with the socalled mitochondrion-rich papillary carcinomas; that TEM and SEM can provide useful evidence for achieving the differential diagnosis between Hurthle cell and so-called mitochondrion-rich papillary carcinomas; and that immunocytochemical studies are useless in the aformentioned differential diagnosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12