PLGA nanoparticles for calcitriol delivery

• Type: Article in International Conference Proceedings Book
• Date: 2015

Authors

M. J. Ramalho (Author) FEUP; J. A. Loureiro (Author) FEUP; B. Gomes (Author) Other; M. F. Frasco (Author) Other; M. A. N. Coelho (Author) Other; M. C. Pereira (Author) Other

Conference proceedings International

Title: Proceedings - 2015 IEEE 4th Portuguese Meeting on Bioengineering, ENBENG 2015

Pages: 1-6

2015 4th IEEE Portuguese Meeting on Bioengineering, ENBENG 2015

26 February 2015 through 28 February 2015

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 10 Citations

INSPEC

Other information

Authenticus ID: P-00G-4SC

DOI: 10.1109/enbeng.2015.7088884

Abstract (EN): Calcitriol, the active metabolite of Vitamin D-3, is a potential anticancer agent but exhibits several drawbacks. Therefore, new therapeutic strategies, as specific drug delivery systems, must be developed in order to overcome those limitations. The aim of this work was to prepare poly(lactide-coglycolide) nanoparticles as drug delivery vehicles for calcitriol. Two formulation parameters, vitamin/polymer ratio and sonication time, were firstly studied and discussed using cholecalciferol as a drug model. Then, calcitriol-loaded poly(lactide-coglycolide) nanoparticles with controlled sizes and properties were prepared. The nanoparticles remained stable at storage conditions for several weeks and they were successfully lyophilized to increase their shelf-life using a crioprotectant. In vitro studies using two human cancer cell lines, S2-013 and A549, demonstrated that bare PLGA NPs are biocompatible.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6