Metabolomics of cocaine: implications in toxicity

• Type: Another Publication in an International Scientific Journal
• Date: 2015

Authors

Ricardo Jorge Dinis Oliveira (Author) FMUP

Journal

Title: Toxicology Mechanisms And Methods

Vol. 25

Pages: 494-500

ISSN: 1537-6516

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 28 Citations

Scopus - 29 Citations

Other information

Authenticus ID: P-00G-PDN

DOI: 10.3109/15376516.2015.1072612

Abstract (EN): Cocaine is the most commonly used illicit drug among those seeking care in Emergency Departments or drug detoxification centers. Cocaine, chemically known as benzoylmethylecgonine, is a naturally occurring substance found in the leaves of the Erythroxylum coca plant. The pharmacokinetics of cocaine is dependent on multiple factors, such as physical/chemical form, route of administration, genetics and concurrent consumption of alcohol. This review aims to discuss metabolomics of cocaine, namely by presenting all known metabolites of cocaine and their roles in the cocaine-mediated toxic effects.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7