Helicobacter pylori cagA Promoter Region Sequences Influence CagA Expression and Interleukin 8 Secretion

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Ferreira, RM (Author) Other; Pinto Ribeiro, I (Author) Other; Wen, XG (Author) Other; Marcos Pinto, R (Author) Other; Mario Dinis Ribeiro (Author) FMUP; Carneiro F (Author) FMUP; Figueiredo C (Author) FMUP

Journal

Title: Journal of Infectious Diseases

Vol. 213

Pages: 669-673

ISSN: 0022-1899

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 35 Citations

Scopus - 39 Citations

Other information

Authenticus ID: P-00K-9DN

DOI: 10.1093/infdis/jiv467

Abstract (EN): Heterogeneity at the Helicobacter pylori cagA gene promoter region has been linked to variation in CagA expression and gastric histopathology. Here, we characterized the cagA promoter and expression in 46 H. pylori strains from Portugal. Our results confirm the relationship between cagA promoter region variation and protein expression originally observed in strains from Colombia. We observed that individuals with intestinal metaplasia were all infected with H. pylori strains containing a specific cagA motif. Additionally, we provided novel functional evidence that strain-specific sequences in the cagA promoter region and CagA expression levels influence interleukin 8 secretion by the host gastric epithelial cells.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5