Skeletal muscle graft on the terminal ileum as a substitute for ileocecal valve: experimental study [Injerto de músculo estriado en íleon terminal como sustituto de la válvula ileocecal: estudio experimental.]

• Type: Article in International Scientific Journal
• Date: 1998

Authors

Parri, FJ (Author) Other; Morales, L (Author) Other; Grau, JM (Author) Other; Estevão-Costa J (Author) FMUP; Julia, V (Author) Other

Journal

Title: Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica

Vol. 11

Pages: 10-14

ISSN: 0214-1221

Publisher: Elsevier

Indexing

Scopus - 1 Citation

Other information

Authenticus ID: P-008-PYK

Abstract (EN): Behavior of a free skeletal muscle graft in contact with intestinal wall is analyzed in rats. On first phase, survival of the graft muscle in relation with previous denervation is studied. Nondenervated muscles suffer necrosis and fibrosis, whereas when denervated 4 weeks before grafting, the muscles are viable. On a second phase, the grafted muscle was studied on the long term. From 8th post-transplant week on, the structural and metabolic features of the graft were similar to normal. On the third phase the efficacy of the muscle implant as a substitute of the ileocecal valve is checked. Germs on either side of the valve (ileum and cecum) are counted in normal rats, rats after valve excision and rats with substitution of the valve by a free skeletal muscle implant. There haven been significant differences between normal and no-valve rats (P < 0.001) and between no-valve and artificial valve rats (P < 0.005). There has not been significant difference between normal rats and artificial valve rats. We conclude that free skeletal muscle survives transplant to intestine, and it prevents bacterial reflux from colon to ileum.

Language: Spanish

Type (Professor's evaluation): Scientific