Leptin and Adiponectin During the First Week After Kidney Transplantation: Biomarkers of Graft Dysfunction?

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Isabel Fonseca (Author) Other; Jose Carlos Oliveira (Author) Other; Josefina Santos (Author) Other; Jorge Malheiro (Author) Other; La Salete Martins (Author) Other; Manuela Almeida (Author) Other; Leonidio Dias (Author) Other; Sofia Pedroso (Author) Other; Luisa Lobato (Author) Other; Antonio Castro Henriques (Author) Other; Denisa Mendonca (Author) ICBAS

Journal

Title: Metabolism: Clinical and Experimental

Vol. 64

Pages: 202-207

ISSN: 0026-0495

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 18 Citations

Scopus - 18 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-00A-35C

DOI: 10.1016/j.metabol.2014.10.003

Abstract (EN): Context and Objective. Based on evidence that leptin and adiponectin are removed from circulation primarily by the kidney, we designed a study to examine the longitudinal changes of these adipokines during the first week after kidney transplantation (KTx) and to test the hypothesis that higher levels of leptin and/or adiponectin could be early biomarkers of delayed graft function (DGF = dialysis requirement during the first post-transplant week) and acute rejection. Study Design. Repeated-measures prospective study. Material and Methods. Forty consecutive adult patients with end-stage renal disease who were undergoing KTx. Leptin and adiponectin were measured in blood samples that were collected before (day-0) and after KTx (days-1, 2, 4 and 7). Linear mixed-models, receiver operating characteristic and area under curve (AUC-ROC) were used. Results. At post-transplant day-1, leptinemia and adiponectinemia declined 43% and 47%, respectively. At all times studied after KTx, the median leptin levels were significantly higher in patients developing DGF (n = 18), but not adiponectin levels. Shortly after KTx (day-1), leptin values were significantly higher in DGF recipients in contrast to patients with promptly functioning kidneys, approximately two times higher when controlling for gender and BMI. The leptin reduction rate between pre-tranplant and one-day after KTx moderately predicted DGF (AUC = 0.73). On day-1, serum leptin predicted DGF (AUC-ROC = 0.76) with a performance slightly better than serum creatinine (AUC-ROC = 0.72), even after correcting for BMI (AUC-ROC = 0.73). Separating this analysis by gender showed that the performance of leptin in predicting DGF for male gender (AUC-ROC = 0.86) improved. Conclusions. Kidney graft function is an independent determinant of leptin levels, but not of adiponectin. Leptin levels at day-1 slightly outperformed serum creatinine in predicting the occurrence of DGF, and more accurately in male gender. No significant association was detected with acute rejection.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6