Patterns of nucleotide and haplotype diversity at ICAM-1 across global human populations with varying levels of malaria exposure

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Felicia Gomez (Author) Other; Gil Tomas (Author) Other; Wen Ya Ko (Author) Other; Alessia Ranciaro (Author) Other; Alain Froment (Author) Other; Muntaser Ibrahim (Author) Other; Godfrey Lema (Author) Other; Thomas B Nyambo (Author) Other; Sabah A Omar (Author) Other; Charles Wambebe (Author) Other; Jibril B Hirbo (Author) Other; Jorge Rocha (Author) FCUP; Sarah A Tishkoff (Author) Other

Journal

Title: Human Genetics

Vol. 132

Pages: 987-999

ISSN: 0340-6717

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 5 Citations

Scientific classification

FOS: Natural sciences > Earth and related Environmental sciences

Other information

Authenticus ID: P-006-7VS

DOI: 10.1007/s00439-013-1284-5

Abstract (EN): Malaria is one of the strongest selective pressures in recent human evolution. African populations have been and continue to be at risk for malarial infections. However, few studies have re-sequenced malaria susceptibility loci across geographically and genetically diverse groups in Africa. We examined nucleotide diversity at Intercellular adhesion molecule-1 (ICAM-1), a malaria susceptibility candidate locus, in a number of human populations with a specific focus on diverse African ethnic groups. We used tests of neutrality to assess whether natural selection has impacted this locus and tested whether SNP variation at ICAM-1 is correlated with malaria endemicity. We observe differing patterns of nucleotide and haplotype variation in global populations and higher levels of diversity in Africa. Although we do not observe a deviation from neutrality based on the allele frequency distribution, we do observe several alleles at ICAM-1, including the ICAM-1 (Kilifi) allele, that are correlated with malaria endemicity. We show that the ICAM-1 (Kilifi) allele, which is common in Africa and Asia, exists on distinct haplotype backgrounds and is likely to have arisen more recently in Asia. Our results suggest that correlation analyses of allele frequencies and malaria endemicity may be useful for identifying candidate functional variants that play a role in malaria resistance and susceptibility.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13