A single high dose of dizocilpine produces long-lasting impairment of the water maze performance in adult rats

• Type: Article in International Scientific Journal
• Date: 2000

Authors

Lukoyanov, NV (Author) Other; Paula Barbosa, MM (Author) Other

Journal

Title: Neuroscience Letters

Vol. 285

Pages: 139-142

ISSN: 0304-3940

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 16 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-001-02X

DOI: 10.1016/s0304-3940(00)01053-3

Abstract (EN): The long-lasting effects of a single high dose treatment with the non-competitive N-methyl-D-aspartate (NMDA) antagonist dizocilpine (MK-801; 10 mg/kg, i.p.) on the water maze performance of rats were investigated. MK-801-treated rats learned to find the escape platform at a slower rate than control animals, and showed increased thigmotaxis during acquisition of the task. However, no differences were found between MK-801 and control groups on the probe trial, during repeated acquisition and on the visible platform task. These findings further support the idea that NMDA antagonists can be used in animal research to model persisting symptomatology of cognitive and psychotic disorders.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4