Two-Dimensional PCA Highlights the Differentiated Antitumor and Antimicrobial Activity of Methanolic and Aqueous Extracts of Laurus nobilis L. from Different Origins

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Maria Ines Dias (Author) Other; Joao C M Barreira (Author) Other; Ricardo C Calhelha (Author) Other; Maria Joao R P Queiroz (Author) Other; Beatriz B P P Oliveira (Author) FFUP; Marina Sokovic (Author) Other; Isabel C F R Ferreira (Author) Other

Journal

Title: BioMed Research International

Vol. 2014

Pages: 1-10

ISSN: 2314-6133

Publisher: Hindawi

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 13 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-009-B6S

DOI: 10.1155/2014/520464

Abstract (EN): Natural matrices are important sources of new antitumor and antimicrobial compounds. Species such as Laurus nobilis L. (laurel) might be used for this purpose, considering its medicinal properties. Herein, in vitro activity against human tumor cell lines, bacteria, and fungi was evaluated in enriched phenolic extracts. Specifically, methanol and aqueous extracts of wild and cultivated samples of L. nobilis were compared considering different phenolic groups. Principal component analysis (PCA) was applied to understand how each extract acts differentially against specific bacteria, fungi, and selected human tumor cell lines. In general, the extract type induced the highest differences in bioactivity of laurel samples. However, from the PCA biplot, it became clear that wild laurel samples were higher inhibitors of tumor cell lines (HeLa, MCF7, NCI-H460, and HCT15). HepG2 had the same response to laurel from wild and cultivated origin. It was also observed that methanolic extracts tended to have higher antimicrobial activity, except against A. niger, A. fumigatus, and P. verrucosum. The differences in bioactivity might be related to the higher phenolic contents in methanolic extracts. These results allow selecting the extract type and/or origin with highest antibacterial, antifungal, and antitumor activity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10