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Stem bark and flower extracts of Vismia cauliflora are highly effective antioxidants to human blood cells by preventing oxidative burst in neutrophils and oxidative damage in erythrocytes

Title
Stem bark and flower extracts of Vismia cauliflora are highly effective antioxidants to human blood cells by preventing oxidative burst in neutrophils and oxidative damage in erythrocytes
Type
Article in International Scientific Journal
Year
2015
Authors
Alessandra Braga Ribeiro
(Author)
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Alessandra Berto
(Author)
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Daniela Ribeiro
(Author)
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Marisa Freitas
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Renan Campos Chiste
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Jesui Vergilio Visentainer
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Eduarda Fernandes
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Journal
Vol. 53
Pages: 1691-1698
ISSN: 1388-0209
Publisher: Taylor & Francis
Scientific classification
FOS: Engineering and technology > Medical engineering
Other information
Authenticus ID: P-00G-S29
Abstract (EN): Context: Vismia cauliflora A. C. Sm. [Hypericaceae (Clusiaceae)] is an Amazonian plant traditionally used by indigenous population to treat dermatosis and inflammatory processes of the skin. Previous research on V. cauliflora extracts suggests its potential to neutralize cellular oxidative damages related to the production of reactive oxygen and nitrogen species. Objective: To determine the activity of stem bark and flower extracts of V. cauliflora on the modulation of oxidative burst in human neutrophils, as well as its potential to inhibit oxidative damage in human erythrocytes. Materials and methods: The modulation of neutrophil's oxidative burst by the ethanolic extracts (0.3-1000 mu g/mL) was determined by the oxidation of specific probes by reactive species. Additionally, the potential of these extracts to inhibit oxidative damage in human erythrocytes was evaluated by monitoring its biomarkers of oxidative stress. Results: Vismia cauliflora extracts presented remarkable capacity to prevent the oxidative burst in activated human neutrophils (IC50 < 15 mu g/mL). However, the maximum percentage of inhibition achieved against hydrogen peroxide was 45%. Concerning the oxidative damage in human erythrocytes, the extracts were able to minimize the tert-butyl hydroperoxide-induced hemoglobin oxidation and lipid peroxidation in a very low concentration range (2.7-18 mu g/mL). Furthermore, only stem bark extract (100 mu g/mL) was able to inhibit the depletion of glutathione (13%). Discussion and conclusion: These results reinforce the therapeutic potential of stem bark and flower extracts of V. cauliflora to heal topical skin disease, namely in the treatment of neutrophil-related dermatosis and skin conditions related to oxidative stress, including skin aging.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 8
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