Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Sandra Costa (Author) Other; Daniela Pinto (Author) Other; Deolinda Pereira (Author) Other; Andre Vasconcelos (Author) Other; Carlos Afonso Lopes (Author) Other; Teresa Osorio (Author) Other; Carlos Lopes (Author) ICBAS; Rui Medeiros (Author) ICBAS

Journal

Title: Cancer Letters

Vol. 246

Pages: 324-330

ISSN: 0304-3835

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 19 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-004-BTZ

DOI: 10.1016/j.canlet.2006.03.014

Abstract (EN): The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case-control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (OR = 2.46 95% CI 1.20-5.06; P = 0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (OR = 3.40 95% CI 1.61-7.15; P = 0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7