The influence of chemokine receptor CCR2 genotypes in the route to cervical carcinogenesis

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Ana Coelho (Author) Other; Ana Matos (Author) Other; Raquel Catarino (Author) Other; Daniela Pinto (Author) Other; Hugo Sousa (Author) Other; Deolinda Pereira (Author) Other; Rui Medeiros (Author) ICBAS

Journal

Title: Gynecologic and Obstetric Investigation

Vol. 64

Pages: 208-212

ISSN: 0378-7346

Publisher: Karger

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 13 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-004-D9V

DOI: 10.1159/000106492

Abstract (EN): Invasive squamous cell carcinomas of the cervix arise from earlier, reversible precursor lesions called low- and high-grade squamous intraepithelial lesions ( LSIL and HSIL, respectively). The aim of our study was to analyse the influence of the CCR2-64I polymorphism in the development of SIL due to its preponderant role in the cervical carcinogenesis and in the progression of these lesions to invasive cervical carcinoma. We conducted a case-control study, analyzing 565 Caucasian women from the north of Portugal. The CCR2-64I polymorphism was analysed through polymerase chain reaction followed by restriction fragment length polymorphism. The frequency of GG, GA and AA genotypes was 76.5, 23.5 and 0.0% respectively, in HSIL patients, and 87.8, 11.1 and 1.1% respectively, in the control group. The G allele frequency was 88.2% in the HSIL group and 93.4% in the control group. Regarding the A allele frequency, it was 11.8% in the HSIL group and 6.6% in the control group. Overall, the frequency of A carrier genotypes was higher in HSIL patients than in the control group ( p = 0.013; OR = 2.21; 95% CI: 1.17 4.15), suggesting that CCR2-64I polymorphism might contribute to the establishment of HSIL, through the disruption of the naturally fragile immune response directed towards human papillomavirus infection. Copyright (c) 2007 S. Karger AG, Basel.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5