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The influence of chemokine receptor CCR2 genotypes in the route to cervical carcinogenesis

Title
The influence of chemokine receptor CCR2 genotypes in the route to cervical carcinogenesis
Type
Article in International Scientific Journal
Year
2007
Authors
Ana Coelho
(Author)
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Ana Matos
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Raquel Catarino
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Daniela Pinto
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Deolinda Pereira
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Rui Medeiros
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Journal
Vol. 64
Pages: 208-212
ISSN: 0378-7346
Publisher: Karger
Scientific classification
FOS: Medical and Health sciences > Clinical medicine
Other information
Authenticus ID: P-004-D9V
Abstract (EN): Invasive squamous cell carcinomas of the cervix arise from earlier, reversible precursor lesions called low- and high-grade squamous intraepithelial lesions ( LSIL and HSIL, respectively). The aim of our study was to analyse the influence of the CCR2-64I polymorphism in the development of SIL due to its preponderant role in the cervical carcinogenesis and in the progression of these lesions to invasive cervical carcinoma. We conducted a case-control study, analyzing 565 Caucasian women from the north of Portugal. The CCR2-64I polymorphism was analysed through polymerase chain reaction followed by restriction fragment length polymorphism. The frequency of GG, GA and AA genotypes was 76.5, 23.5 and 0.0% respectively, in HSIL patients, and 87.8, 11.1 and 1.1% respectively, in the control group. The G allele frequency was 88.2% in the HSIL group and 93.4% in the control group. Regarding the A allele frequency, it was 11.8% in the HSIL group and 6.6% in the control group. Overall, the frequency of A carrier genotypes was higher in HSIL patients than in the control group ( p = 0.013; OR = 2.21; 95% CI: 1.17 4.15), suggesting that CCR2-64I polymorphism might contribute to the establishment of HSIL, through the disruption of the naturally fragile immune response directed towards human papillomavirus infection. Copyright (c) 2007 S. Karger AG, Basel.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 5
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