Chemical Study and Biological Activity Evaluation of Two Azorean Macroalgae:Ulva rigida and Gelidium microdon

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Madalena Silva (Author) Other; Luís M. M. Vieira (Author) ICBAS; Ana Paula Almeida (Author) FFUP; Artur M. S. Silva (Author) Other; Ana M. L. Seca (Author) Other; M. Carmo Barreto (Author) Other; Ana I. Neto (Author) Other; Madalena Pedro (Author) Other; Eugénia Pinto (Author) FFUP; Anake Kijjoa (Author) ICBAS

Journal

Title: Oceanography: Open Acess

Vol. 1 No. 1

ISSN: 2332-2632

Publisher: OMICS International

Scientific classification

FOS: Natural sciences > Biological sciences

CORDIS: Natural sciences > Biological sciences

Other information

DOI: 10.4172/2332-2632.1000102

Abstract (EN): The green macroalga Ulva rigida C. Agardh (Chlorophyta) and the red macroalga Gelidium microdon Kützing (Rhodophyta), collected from the Azorean archipelago, were investigated for their secondary metabolites and their in vitro growth inhibitory effect on three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma), as well as for their antifungal and antibacterial activities. The methanol extract of U. rigida furnished isofucosterol (1), 7(E)-3β-hydroxy-5α,6α-epoxymegastigmane (2) and (+)-dehydrovomifoliol (3) while the methanol extract of G. microdon yielded cholesterol (4) and lumichrome (5). The crude extracts of both macroalgae were found to be moderately active against the three cell lines whereas compound 1 showed a weak effect and compound 2 was inactive. The crude extracts of the two macroalgae were found to be moderately active against some fungi and bacteria while compounds 1 and 2 were inactive against all microorganisms tested.

Language: Portuguese

Type (Professor's evaluation): Scientific