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Dermic diffusion and stratum corneum: A state of the art review of mathematical models

Title
Dermic diffusion and stratum corneum: A state of the art review of mathematical models
Type
Another Publication in an International Scientific Journal
Year
2014
Authors
Ana Couto
(Author)
Other
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Ruben Fernandes
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Natalia N S Cordeiro
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Sara S Reis
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Rogerio T Ribeiro
(Author)
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Ana M Pessoa
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Journal
Vol. 177
Pages: 74-83
ISSN: 0168-3659
Publisher: Elsevier
Scientific classification
FOS: Natural sciences > Chemical sciences
Other information
Authenticus ID: P-009-6VZ
Abstract (EN): Transdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 10
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