Radiopharmaceuticals and applications [Preparações radiofarmacêuticas e suas aplicações]

• Type: Another Publication in an International Scientific Journal
• Date: 2006

Authors

Oliveira, R (Author) Other; Santos, D (Author) Other; Ferreira, D (Author) FFUP; Coelho, P (Author) Other; Veiga, F (Author) Other

Journal

Title: Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences

Vol. 42

Pages: 151-165

ISSN: 1516-9332

Publisher: Universidade de São Paulo

Indexing

ISI Web of Knowledge

Scopus - 10 Citations

Other information

Authenticus ID: P-007-G4B

Abstract (EN): Radiopharmaceuticals are substances without pharmacological activity that are used in Nuclear Medicine for diagnosis and therapy for several diseases. Diagnosis radiopharmaceuticals generally emit ¿ radiation or positrons (ß -), because their decay originates penetrating electromagnetic radiation that can cross the tissues and he externally detected. Therapeutic radiopharmaceuticals must include in their composition ionized particles emission nucleus (¿, ß - or Auger electrons), since their action is based in selective tissue destruction. There are two main methods for image acquisition: SPECT (Single Photon Emission Computerized Tomography) that uses ¿ emission radionuclides ( 99mTc, 123I, 67G¿, 201Tl) and PET (Positron Emission Tomography) that uses positron emission radionuclides like 11C, 13N, 15O, 18F. Radiopharmaceuticals can be classified into perfusion radiopharmaceuticals (first generation) or specific radiopharmaceuticals (secondgeneration). Perfusion radiopharmaceuticals are transported in the blood e reach the target organ in the direct proportion of the blood stream. Specific radiopharmaceuticals contain a biologically active molecule that binds to cellular receptors that must remain biospecific after binding to the radiopharmaceutical. For this type of radiopharmaceuticals, tissue or organ uptake is determined by the biomolecule capacity of recognizing receptors in those biological structures. Radiopharmaceuticals are produced ready to use, in cold kits or in autologal preparations. According to the preparation type there is a different quality control procedure. Most of the radiopharmaceuticals used nowadays are of the perfusion type. Research focus in the development of specific radiopharmaceuticals that can provide information, at the molecular level, of biochemical alterations associated to different pathologies.

Language: Portuguese

Type (Professor's evaluation): Scientific