Nitric oxide in the pathophysiology of myocardial dysfunction in heart failure [O óxido nítrico na fisiopatologia da disfunção miocárdica na insuficiência cardíaca]

• Type: Another Publication in an International Scientific Journal
• Date: 2004

Authors

Bras Silva, C (Author) FCNAUP; Leite Moreira, AF (Author) Other

Journal

Title: Revista Portuguesa de Cardiologia

Vol. 23 No. 25

Pages: II105-II119

ISSN: 0870-2551

Publisher: Sociedade Portuguesa De Cardiologia

Indexing

ISI Web of Knowledge

Scopus - 1 Citation

Other information

Authenticus ID: P-007-EXA

Abstract (EN): Nitric oxide (NO) modulates several parameters of myocardial function at the autocrine and paracrine level. Various studies have demonstrated that endogenously NO, regulates myocardial contractility, distensibility, heart rate, coronary vasodilation, myocardial oxygen consumption, mitochondrial respiration and apoptosis. In pathological situations, particularly heart failure (HF), NO synthesis and activity are altered and its effects are controversial. Thus, NO can have beneficial or deleterious actions, depending on: (i) the cellular and enzymatic source, (ii) the amount produced and/or released, (iii) the presence of reactive oxygen species, (iv) interactions with neurohumoral and other stimuli, (v) the tanget issue and (vi) the activation of different cyclic GMP (cGMP)-dependent and independent subcellular signal transduction pathways. In this paper we review the main physiological actions of NO in normal myocardial function and its role in the pathophysiology of HF, as well as the cellular and molecular mechanisms underlying these effects. We also include a brief mention of therapeutic approaches are which directly or indirectly related with the bioavailability of this mediator.

Language: Portuguese

Type (Professor's evaluation): Scientific