Flavonoids as dopaminergic neuromodulators

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Meireles, M. (Author) FMUP; Moura, E. (Author) FMUP; Vieira-Coelho, M.A. (Author) FMUP; Santos-Buelga, C. (Author) Other; Gonzalez-Manzano, S. (Author) Other; Dueñas, M. (Author) Other; Mateus, N. (Author) FCUP; Faria, Ana (Author) FCNAUP; Calhau, C. (Author) FMUP

Journal

Title: Molecular Nutrition and Food Research

Vol. 60 No. 3

Pages: 495-501

ISSN: 1613-4125

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 16 Citations

Pubmed / Medline

Scientific classification

CORDIS: Health sciences

FOS: Medical and Health sciences

Other information

Authenticus ID: P-00K-8C2

DOI: 10.1002/mnfr.201500557

Abstract (EN): SCOPE: The present study aimed to characterize and evaluate flavonoids effects on organic cation uptake in neuronal cells. METHODS AND RESULTS: Uptake experiments were conducted using radiolabeled methyl-4-phenylpyridinuim ([3 H]-MPP+ ), in human neuronal dopaminergic cells, SH-SY5Y. Catechin did not alter [3 H]-MPP+ uptake, however its metabolite 4'-methyl-catechin decreased it by almost 50%. Epicatechin and its methylated metabolites also decreased [3 H]-MPP+ uptake. Interestingly, the quercetin flavonol and its metabolite conjugated with glucuronic acid, as well as the flavanones naringenin and hesperitin, increased [3 H]-MPP+ uptake. CONCLUSION: These results showed that different classes of flavonoids, as well as its metabolites, differently influence neuronal organic cation uptake. Several xeno- and endobiotics, including neurotransmitters, are organic cations. Specific food recommendations may be beneficial in pathological conditions where levels of neurotransmitters, as dopamine, are either increased or decreased. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved. KEYWORDS: Dopamine transporter; Dopaminergic cells; Flavonoids; Methyl-4-phenylpyridinuim; Organic cation transport

Language: English

Type (Professor's evaluation): Scientific

Notes: <a href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS&DestLinkType=FullRecord&KeyUT=000372844200002">Indexado na ISI Web of Science</a> <a href="https://www.ncbi.nlm.nih.gov/pubmed/26582321">Indexado na Pubmed</a> <a href="http://www.scopus.com/record/display.url?eid=2-s2.0-84959466412&origin=inward">Indexado na Scopus</a>

No. of pages: 7