Dietary lipid levels have a remarkable impact on the expression of growth-related genes in Senegalese sole (Solea senegalensis Kaup)

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Campos, C (Author) Other; Valente, LMP (Author) ICBAS; Borges, P (Author) Other; Bizuayehu, T (Author) Other; Fernandes, JMO (Author) Other

Journal

Title: Journal of Experimental Biology

Vol. 213

Pages: 200-209

ISSN: 0022-0949

Publisher: The Company of Biologists Ltd.

Indexing

ISI Web of Knowledge - 62 Citations

Scopus - 77 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-003-9QS

DOI: 10.1242/jeb.033126

Abstract (EN): In Senegalese sole (Solea senegalensis Kaup), growth is negatively correlated to dietary lipid levels. To understand the molecular basis of this effect a molecular toolbox of 12 genes, including fgf6, fst, mstn1, myf5, mrf4, myod1, myod2, myog, myHC, mylc2, igf1r and insr, was developed. The expression profiles of these genes were investigated in white muscle and liver of fish fed with three dietary lipid levels (4%, 12% and 20%). The expression of igf-I and igf-II was also examined. MRFs and myosins were only expressed in the muscle and, except for myf5, the general trend was a decrease in expression with an increase in dietary lipids. Fgf6 was identified for the first time in liver and its expression augmented in hepatic tissues with increasing dietary lipid levels. A similar tendency was observed for mstn1 and igf-I. The opposite was observed for igf1r expression in muscle and liver. Myog, mrf4, mylc2 and igf1r were highly correlated with growth and nutrient utilisation indices. In addition to its practical implications, this work provides a valuable contribution towards our understanding of the genetic networks controlling growth in teleosts.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10