Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Teresa M Coque (Author) Other; Angela Novais (Author) Other; Alessandra Carattoli (Author) Other; Laurent Poirel (Author) Other; Johann Pitout (Author) Other; Luisa Peixe (Author) FFUP; Fernando Baquero (Author) Other; Rafael Canton (Author) Other; Patrice Nordmannj (Author) Other

Journal

Title: Emerging Infectious Diseases

Vol. 14 No. 2

Pages: 195-200

ISSN: 1080-6040

Publisher: Centers for Disease Control and Prevention (CDC)

Indexing

ISI Web of Knowledge - 477 Citations

Scopus - 558 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-004-1PB

DOI: 10.3201/eid1402.070350

Abstract (EN): We analyzed 43 CTX-M-15-producing Escherichia coli isolates and 6 plasmids encoding the b/a(CTX-M-15) gene from Canada, India, Kuwait, France, Switzerland, Portugal, and Spain. Most isolates belonged to phylogroups B2 (50%) and D (25%). An EC-B2 strain of clonal complex sequence type (ST) 131 was detected in all countries; other B2 isolates corresponded to ST28, ST405, ST354, and ST695 from specific areas. EC-D strains were clonally unrelated but isolates from 3 countries belonged to ST405. All CTX-M-15 plasmids corresponded to IncFII group with overrepresentation of 3 Hpal-igested plasmid DNA profiles (A, B and C; 85-120kb, similarity >70%). Plasmid A was detected in EC-B2 strains (ST131, ST354, or ST405), plasmid C was detected in B2 and D strains, and plasmid B was confined to worldwide-disseminated ST131. Most plasmids contained b/a(OXA-1') aac(6)-lb-cr, and b/a(TEM-1). Worldwide dissemination of CTX-M-15 seems to be determined by clonal complexes ST131 and ST405 and multidrug-resistant IncFII plasmids.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6