Role of Common bla(OXA-24/OXA-40)-Carrying Platforms and Plasmids in the Spread of OXA-24/OXA-40 among Acinetobacter Species Clinical Isolates

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Filipa Grosso (Author) Other; Sandra Quinteira (Author) FCUP; Laurent Poirel (Author) Other; Angela Novais (Author) Other; Luisa Peixe (Author) FFUP

Journal

Title: Antimicrobial Agents and Chemotherapy

Vol. 56

Pages: 3969-3972

ISSN: 0066-4804

Publisher: American Society for Microbiology

Indexing

ISI Web of Knowledge - 43 Citations

Scopus - 44 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-002-8GA

DOI: 10.1128/aac.06255-11

Abstract (EN): The spread of OXA-24/OXA-40 (OXA-24/40)-producing Acinetobacter spp. in the Iberian Peninsula has been strongly influenced by clonal expansion, but the role of horizontal gene transfer has scarcely been explored. bla(OXA-24/40)-carrying plasmids and genetic environments were characterized in representative (n = 15) Acinetobacter species clinical isolates (obtained between 2001 and 2007) by Acinetobacter baumannii PCR-based replicon typing, sequencing, hybridization, and restriction fragment length polymorphism. Besides the identification of bla(OXA-24/40) within the chromosomes of some isolates, the circulation of common bla(OXA-24/40)-carrying plasmids (30-kb repA_AB; 10-kb aci2) and genetic backbones among Acinetobacter spp. was demonstrated.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4