Serum levels of VEGF and TNF-a and their association with C-reactive protein in patients with endometriosis

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Xavier, P (Author) Other; Belo, L (Author) FFUP; Beires, J (Author) Other; Rebelo, I (Author) FFUP; Martinez de Oliveira, J (Author) Other; Lunet, N (Author) FMUP; Barros, H (Author) FMUP

Journal

Title: Archives of Gynecology and Obstetrics

Vol. 273 No. 4

Pages: 227-231

ISSN: 0932-0067

Publisher: Springer Nature

Indexing

ISI Web of Knowledge

Scopus - 103 Citations

Other information

Authenticus ID: P-007-EHD

DOI: 10.1007/s00404-005-0080-4

Abstract (EN): Objective: To compare serum levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-¿), and C-reactive protein (CRP) throughout the menstrual cycle in women with and without endometriosis and to quantify the association between these serum markers. Methods: Twenty five endometriosis patients (ASRM stage III-IV) and 13 controls were followed through one menstrual cycle. VEGF, TNF-¿ and CRP concentrations were measured with enzyme-linked immunosorbent assay in each of the four cycle phases (early and late proliferative and early and late secretory). Non-parametric methods and Pearson's correlation coefficients were used for statistical analysis. Results: Increased serum levels of VEGF in secretory phases and of TNF-¿ in all cycle phases were observed. A positive correlation between CRP and VEGF was found in endometriosis patients but not in controls. Conclusions: Our results suggest that excessive systemic angiogenic activity is a feature of patients with endometriosis. © Springer-Verlag 2005.

Language: English

Type (Professor's evaluation): Scientific