Determination of ketoprofen based on its quenching effect in the fluorescence of quantum dots

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Lucia Molina Garcia (Author) Other; Joao L M Santos (Author) FFUP; Antonio Ruiz Medina (Author) Other; Eulogio J Llorent Martinez (Author) Other

Journal

Title: Journal of Food and Drug Analysis

Vol. 21

Pages: 426-431

ISSN: 1021-9498

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 9 Citations

Scientific classification

FOS: Agrarian Sciences > Other Agrarian Sciences

Other information

Authenticus ID: P-008-PJT

DOI: 10.1016/j.jfda.2013.09.007

Abstract (EN): Ketoprofen is a potent nonsteroidal anti-inflammatory drug used for the treatment of inflammatory diseases and musculoskeletal injuries. Taking into account the increasing consumption of this drug, it is important to develop a rapid, easy, and reliable analytical strategy for its quality control. In this work, we present a novel method for ketoprofen determination, based on its quenching effect produced in the fluorescence of CdTe quantum dots modified by mercaptopropionic acid. Under optimized conditions, the method was linear in the range of 7.5-100 mu g/mL, with a detection limit of 2.3 mu g/mL and relative standard deviations lower than 2%. It was applied to the determination of ketoprofen in pharmaceutical formulations, obtaining results in good agreement with those provided by the manufacturer. Copyright

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6