Effect of natural 2,5-diaryl-3,4-dimethyltetrahydrofuran lignans on complement activation, lymphocyte proliferation, and growth of tumor cell lines

• Type: Article in International Scientific Journal
• Date: 1998

Authors

Nascimento, M.S.J. (Author) FFUP; Pedro, M. (Author) Other; Cerqueira, F. (Author) Other; Margarida M. S. M. Bastos (Author) FEUP; Vieira, L.M. (Author) ICBAS; Kijjoa, A. (Author) ICBAS; Pinto, M.M.M. (Author) FFUP

Journal

Title: Pharmaceutical Biology

Vol. 42 No. 6

Pages: 449-453

ISSN: 1388-0209

Publisher: Taylor & Francis

Indexing

Scopus

Scientific classification

FOS: Medical and Health sciences > Health sciences

Other information

DOI: 10.1080/13880200490894824

Abstract (EN): (+)-Machillin F, isolated from the bark of Persea membranacea, Kosterm and four other 2,5-diaryl-3,4-dimethyltetrahydrofuran-type lignans from Talauma hodgsonii Hook, F. & Thoms., (-)-galbacin, (-)-talaumidin, (-)-talaumidin methyl ether, and acetyl talaumidin, were evaluated for their influence on the classical and alternative pathways of activation of human complement system, mitogen-induced proliferation of human lymphocytes, and growth of human tumor cell lines. All these lignans exhibited moderate inhibitory activities. (+)-Machillin F showed the highest anticomplementary activity, and (-)-talaumidin methyl ether exhibited the strongest suppressive effect on lymphocyte proliferation. (-)-Talaumidin, acetyl talaumidin, and (+)-machillin F inhibited the growth of MCF-7, TK-10, and UACC-62 cell lines, whereas (-)-galbacin was inactive against UACC-62 and (-)-talaumidin methyl was inactive against both TK-10 and UACC-62. A characterization of the structural features of these lignans that is important to their biological activities is discussed.

Language: English

Type (Professor's evaluation): Scientific