Analytical potential of mesofluidic lab-on-a-valve as a front end to column-separation systems

• Type: Another Publication in an International Scientific Journal
• Date: 2011

Authors

Manuel Miro (Author) Other; Hugo M Oliveira (Author) Other; Marcela A Segundo (Author) FFUP

Journal

Title: TrAC - Trends in Analytical Chemistry

Vol. 30 No. 8

Pages: 153-164

ISSN: 0165-9936

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 29 Citations

Scopus - 33 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-002-XTR

DOI: 10.1016/j.trac.2010.08.007

Abstract (EN): The lab-on-a-valve (LOV) integrated microdevice has recently attracted much attention as a functional mesofluidic platform for programmable, pressure-driven flow as compared to lab-on-a-chip counterparts. We review the current state of the art of LOV as a versatile front end to column-separation techniques, namely, liquid chromatography (LC), gas chromatography (GC) and capillary electrophoresis (CE) for automatic mesofluidic handling at the low-microliter level, in-line sample processing and introducing the appropriate form of the analyte into the instrument for separation or detection. The open architecture of the LOV monolith unit has been to date exploited to accommodate micro solid-phase extraction in a renewable fashion, the so-called bead-injection analysis, encompassing reversed-phase materials and molecularly imprinted polymers, and in-valve microscale affinity chromatography. A plethora of interfaces have been recently devised for reliable injection of minute, well-defined volumes of analyte-containing solutions into LC,GC or CE We illustrate these applications with representative examples in environmental and bioanalytical arenas.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12