Malignant peripheral nerve sheath tumour-like primary cutaneous malignant melanoma

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Cruz, J (Author) Other; Reis, JS (Author) Other; Lopes, JM (Author) FMUP

Journal

Title: JOURNAL OF CLINICAL PATHOLOGY

Vol. 57

Pages: 218-220

ISSN: 0021-9746

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 12 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-BS7

DOI: 10.1136/jcp.2003.11627

Abstract (EN): Malignant melanoma is known for its protean cytomorphological features, architectural patterns, and stromal changes, in addition to its ability to mimic various benign and malignant non-melanocytic tumours. Anecdotal cases of metastatic malignant melanoma simulating soft tissue sarcomas have been reported. Interestingly, this mimicry is more often seen in recurrent lesions and metastatic deposits. This report describes a case of a primary spindle cell cutaneous malignant melanoma with a prominent neural-like fascicular pattern and nuclear palisading, simulating a conventional malignant peripheral nerve sheath tumour (MPNST). Clinical, microscopic, and immunohistochemical features of the different entities included in the differential diagnosis of cutaneous spindle cell malignant tumours, such as MPNST, atypical fibroxanthoma, and spindle cell squamous cell carcinoma are discussed. Of note, the presence of an atypical epidermal or junctional component, cell pigmentation, and cell nesting, in addition to diffuse and strong reactivity for S-100 protein and other melanocytic markers, are helpful in the diagnosis of these troublesome lesions.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3