Dislipidemia and oxidative stress in mild and in severe psoriasis as a risk for cardiovascular disease

• Type: Article in International Scientific Journal
• Date: 2001

Authors

Rocha Pereira, P (Author) Other; Santos Silva, A (Author) FFUP; Rebelo, I (Author) FFUP; Figueiredo, A (Author) Other; Quintanilha, A (Author) ICBAS; Teixeira, F (Author) Other

Journal

Title: Clinica Chimica Acta

Vol. 303

Pages: 33-39

ISSN: 0009-8981

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 156 Citations

Scopus - 199 Citations

Scientific classification

FOS: Engineering and technology > Medical engineering

Other information

Authenticus ID: P-000-WWV

DOI: 10.1016/s0009-8981(00)00358-2

Abstract (EN): Psoriasis is a common chronic and recurrent inflammatory skin disorder that has been associated with oxidative stress, abnormal plasma lipid metabolism and with high frequency of cardiovascular events. This prevalence seems to be related to the severity of psoriasis, as it occurs more frequently in patients presenting large areas of the body affected with psoriasis lesions. The aim of our work was to evaluate the development of oxidative stress and of dislipidemia in psoriasis, and to look for a correlation between their levels and worsening of psoriasis. We evaluated lipid profile, total antioxidant capacity, antioxidant vitamins A and E, and lipoperoxidation products. The study was performed in controls and in patients presenting mild and severe psoriasis. Patients presented risk changes in lipid profile (a rise in cholesterol (P<0.01), triglycerides (P<0.001), low density lipoprotein cholesterol (P<0.01), very low density lipoprotein cholesterol (P<0.01), apolipoprotein B (P<0.001) and lipoprotein(a) (P<0.001); and a reduction in high density lipoprotein cholesterol (P<0.001)), a rise in lipoperoxidation products (P<0.001) and a reduction in total antioxidant capacity (P<0.001) and in antioxidant vitamins A (P<0.001) and E (P<0.05). Moreover, we found that the worsening of psoriasis was associated with the enhancement of oxidative stress and of the lipid I risk changes. Our data suggest that psoriasis patients must be considered as a group at risk for cardiovascular disease and that this risk seems to be higher in severe psoriasis. In addition, a possible benefit of an enriched diet ol of a supplement of vitamins A and E in psoriasis patients should be further studied.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7