Chitosan/siRNA Nanoparticles Biofunctionalize Nerve Implants and Enable Neurite Outgrowth

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Ursula Mittnacht (Author) Other; Hanna Hartmann (Author) Other; San Hein (Author) Other; Hugo Oliveira (Author) Other; Mingdong Dong (Author) Other; Ana P Pego (Author) FEUP; Jorgen Kjems (Author) Other; Kenneth A Howard (Author) Other; Burkhard Schlosshauer (Author) Other

Journal

Title: Nano Letters

Vol. 10

Pages: 3933-3939

ISSN: 1530-6984

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 54 Citations

Scopus - 67 Citations

Scientific classification

FOS: Engineering and technology > Materials engineering

Other information

Authenticus ID: P-003-2K5

DOI: 10.1021/nl1016909

Abstract (EN): Microstructured 2 0 Aim thick polymer filaments used as nerve implants were loaded with chitosan/siRNA nanoparucles to promote nerve regeneration and ensure local delivery of nanotherapeutics The stable nanoparticles were rapidly internalized by cells and did not affect cell viability Target mRNA was successfully reduced by 65-75% and neurite outgrowth was enhanced even in an inhibitory environment This work, thus. supports the application of nanobiofunctionalized implants as a novel approach for spinal cord and nerve repair

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7