TP53 codon 72 polymorphism and risk for cervical cancer in Portugal

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Santos, AM (Author) Other; Sousa, H (Author) Other; Catarino, R (Author) Other; Pinto, D (Author) Other; Pereira, D (Author) Other; Vasconcelos, A (Author) Other; Matos, A (Author) Other; Lopes, C (Author) ICBAS; Medeiros, R (Author) ICBAS

Journal

Title: Cancer Genetics and Cytogenetics

Vol. 159

Pages: 143-147

ISSN: 0165-4608

Publisher: Elsevier B.V.

Indexing

ISI Web of Knowledge - 38 Citations

Scopus - 37 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-2YN

DOI: 10.1016/j.cancergencyto.2004.10.005

Abstract (EN): High-risk human papillomavirus are essential for the development of cervical cancer; however, TP53 is the most frequently altered tumor suppressor gene among tumors and is described as a cofactor for cervical carcinogenesis. TP53 has two common polymorphic forms encoding either proline or arginine, at position 72, and the presence of homozygous arginine has been reported as a risk factor for cervical cancer in many populations. We evaluated the effect of this TP53 polymorphism in a northern Portuguese population. We analyzed blood samples of 385 women; 20 with low-grade squamous intraepithelial lesion (SIL), 56 with high-grade SIL, 164 with invasive cervical cancer, and 145 healthy controls, using allele specific-polymerase chain reaction methodology. We observed an increased frequency of the Arg/Arg genotype in the cancer group, but no statistical significance was found between cases and controls (P > 0.05). Our results indicate that there is no association between the presence of the Arg allele in codon 72 of TP53 polymorphism and risk of cervical cancer in our population.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5