Molecular Study of the PCA3 Gene: Genotypic Analysis of PCA3 Polymorphism -845G > A and Metastatic Prostate Cancer

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Silvia Fontenete (Author) Other; Augusto Nogueira (Author) Other; Francisco Pina (Author) Other; Francisco Lobo (Author) Other; Avelino Fraga (Author) Other; Fernando Calais da Silva (Author) Other; Rui Medeiros (Author) ICBAS

Journal

Title: Genetic Testing and Molecular Biomarkers

Vol. 16

Pages: 418-422

ISSN: 1945-0265

Publisher: Mary Ann Liebert

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-002-AE9

DOI: 10.1089/gtmb.2011.0160

Abstract (EN): Aims: The prostate cancer gene 3 (PCA3) is a prostate-specific, non-protein-coding RNA. It is overexpressed in prostate cancer compared with the normal prostate and has a negative expression in other tissues. This case-control study sought to analyze the frequency of the polymorphism PCA3 -845 G>A in participants without prostate cancer and patients with metastatic prostate cancer. Results: Carriers of GA and AA genotype had a higher risk for metastatic prostate cancer (odds ratio [OR] for genotype GA, 1.79 [95% confidence interval (CI), 1.14-2.29]; p = 0.007; OR for genotype AA, 2.38 [95% CI, 1.22-4.65]; p = 0.006). Furthermore, the recessive model showed that A allele carriers have an increased risk for developing metastatic prostate cancer (OR, 1.91 [95% CI, 1.26-2.90]; p = 0.001). Conclusions: These results suggest a link between PCA3 and metastatic prostate cancer. The evaluation of individual genetic profiles, according to the PCA3 -845 G > A polymorphism, may elucidate the function of this gene and the mechanisms involved in its regulation and role in prostate cancer.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5