Haemochromatosis gene (HFE) mutations in viral-associated neoplasia: Linkage to cervical cancer

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Cardoso, CS (Author) Other; Araujo, HC (Author) Other; Cruz, E (Author) Other; Afonso, A (Author) Other; Mascarenhas, C (Author) Other; Almeida, S (Author) Other; Moutinho, J (Author) Other; Lopes, C (Author) ICBAS; Medeiros, R (Author) ICBAS

Journal

Title: Biochemical and Biophysical Research Communications

Vol. 341

Pages: 232-238

ISSN: 0006-291X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 15 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-004-MSX

DOI: 10.1016/j.bbrc.2005.12.174

Abstract (EN): The present study examines the frequency of the two main HIE mutations (C282Y and H63D) in a randomly selected population of 346 individuals including 201 DNA samples from women with cervical neoplasia (including high-grade squamous intraepithelial lesions and invasive squamous cell carcinoma) and a control population of 146 women from the same geographical area. We found a significantly lower risk of development of cervical neoplasia in H63D carriers (OR = 0.56; 95% CI 0.35-0.92-1 It - 0.01). Multivariate logistic regression analysis confirms this observation (OR = 0.55; 95% CI 0.35-0.88, It = 0.01). Regarding the C282Y mutation no association was found (OR - 1.32; 95% CI 0.53-3.33; It = 0.52). In addition, a significant difference between H63D carrier and non-carrier women on the time-to-onset of cervical lesions was observed (log-rank test: p = 0.0012). These results indicate that HFE could be considered a candidate modifier gene of viral-related neoplasia such as cervical carcinoma possibly by a dual role on iron metabolism and immunological system.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7