Association of the A870G cyclin D1 gene polymorphism with genetic susceptibility to nasopharyngeal carcinoma

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Catarino, RJ (Author) Other; Breda, E (Author) Other; Coelho, V (Author) Other; Pinto, D (Author) Other; Sousa, H (Author) Other; Lopes, C (Author) ICBAS; Medeiros, R (Author) ICBAS

Journal

Title: Head and Neck

Vol. 28

Pages: 603-608

ISSN: 1043-3074

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 33 Citations

Scopus - 34 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-004-JTK

DOI: 10.1002/hed.20377

Abstract (EN): Background. Nasopharyngeal cancer (NPC) is multifactorial, and the genetic background may be a crucial etiologic factor. Cyclin D1 (CCND1) is a key regulator of the cell cycle, and its altered activity is associated with the development of cancer. Methods. We analyzed the A870G CCND1 polymorphism by polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) in 281 individuals, including 94 patients with NPC and 187 healthy individuals. Results. Our results indicate that individuals carrying two G alleles have a 2.17-fold increase in the risk for the development of NPC (odds ratio [OR], 2.17; 95% confidence interval [Cl], 1.19-3.98; p =.016). Age-adjusted logistic regression analysis confirmed this association (adjusted odds ratio [aOR], 2.14; 95% Cl, 1.14-4.04; p =.018). Multivariate analysis demonstrates an independent association between GG CCND1 genotype (aOR, 2.06), male sex (aOR, 2.66), and age at diagnosis (aOR, 2.02) regarding the development of undifferentiated NPC. The proportion of NPC cases attributable to the GG CCND1 genotype was 14,76%. Conclusions. Our results may be important in the definition of a biologic predictive profile for the development of NPC within ourpopulation. (c) 2006 Wiley Periodicals, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6