Oncogenic virus-associated neoplasia: A role for cyclin D1 genotypes influencing the age of onset of disease?

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Catarino, R (Author) Other; Pereira, D (Author) Other; Breda, E (Author) Other; Coelho, A (Author) Other; Matos, A (Author) Other; Lopes, C (Author) ICBAS; Medeiros, R (Author) ICBAS

Journal

Title: Biochemical and Biophysical Research Communications

Vol. 370

Pages: 118-122

ISSN: 0006-291X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 18 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-003-ZBY

DOI: 10.1016/j.bbrc.2008.03.039

Abstract (EN): Cyclin D1 (CCND1) is a key regulatory protein at the G1/S checkpoint of the cell cycle. The purpose of our study was to assess the role of CCND1 genotypes influencing the age of onset of oncogenic virus-associated neoplasia. We conducted a hospital-based case-control study of 581 individuals, including 247 controls and 334 cases (108 nasopharyngeal and 226 cervical cancer cases). The polymorphism analysis was performed in blood samples by PCR-RFLP methodology. Age-adjusted logistic regression analysis indicates that individuals carrying two G-alleles have an increased genetic susceptibility for the development of oncogenic virus-associated cancers (aOR = 2.02, 95% CI 1.30-3.14, P = 0.002). Moreover, our results indicate that the waiting time for onset of oncogenic virus-associated neoplasia in patients homozygous (GG) for CCND1 genotypes (52 years) was 12 years earlier in comparison with patients carrying AG or AA genotypes (60 years) (log-rank test: P = 0.0003). Our results may be important in contributing to a more extensive knowledge of the mechanisms involved in oncogenic virus-associated carcinogenesis, as CCND1 may be an important target for the development of new strategies for cancer treatment and prevention.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5