Model for Osteosarcoma-9 as a potent factor in cell survival and resistance to apoptosis

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Ekaterini Vourvouhaki (Author) Other; Carla Carvalho (Author) Other; Paulo Aguiar (Author) Other

Journal

Title: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics

Vol. 76

ISSN: 1539-3755

Publisher: American Physical Society

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 8 Citations

Scientific classification

FOS: Natural sciences > Physical sciences

Other information

Authenticus ID: P-004-97P

DOI: 10.1103/physreve.76.011926

Abstract (EN): In this paper we use a simple model to explore the function of the gene Osteosarcoma-9 (OS-9). We are particularly interested in understanding the role of this gene as a potent anti-apoptotic factor. The theoretical description is constrained by experimental data from induction of apoptosis in cells where OS-9 is overexpressed. The data available suggest that OS-9 promotes cell viability and confers resistance to apoptosis, potentially implicating OS-9 in the survival of cancer cells. Three different apoptosis-inducing mechanisms were tested and are modeled here. A more complex and realistic model is also discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10