Potential Cardiovascular Risk Protection of Bilirubin in End-Stage Renal Disease Patients under Hemodialysis

• Type: Article in International Scientific Journal
• Date: 2014

Authors

do Sameiro Faria, M (Author) Other; Kohlova, M (Author) Other; Ribeiro, S (Author) Other; Rocha Pereira, P (Author) Other; Teixeira, L (Author) Other; Nascimento, H (Author) Other; Reis, F (Author) Other; Miranda, V (Author) Other; Bronze da Rocha, E (Author) Other; Quintanilha, A (Author) Other; Belo, L (Author) FFUP; Costa, E (Author) Other; Santos Silva, A (Author) FFUP

Journal

Title: BioMed Research International

Vol. 2014

Final page: 175286

ISSN: 2314-6133

Publisher: Hindawi

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 1 Citation

Other information

Authenticus ID: P-00A-16K

DOI: 10.1155/2014/175286

Abstract (EN): We evaluated the potential cardiovascular risk protection of bilirubin in hemodialysis (HD) patients. An enlarged set of studies were evaluated in 191 HD patients, including hematological study, lipid profile, iron metabolism, nutritional, inflammatory markers, and dialysis adequacy. The TA duplication screening in the UDP-glucuronosyltransferase 1 A1 (UGT1A1) promoter region was also performed. The UGT1A1 genotype frequencies in HD patients were 49.2%, 42.4%, and 8.4% for 6/6, 6/7, and 7/7 genotypes, respectively. Although no difference was found in UGT1A1 genotype distribution between the three tertiles of bilirubin, significant differences were found with increasing bilirubin levels, namely, a decrease in platelet, leukocyte, and lymphocyte counts, transferrin, oxidized low-density lipoprotein (ox-LDL), ox-LDL/low-density lipoprotein cholesterol ratio, apolipoprotein (Apo) A, Apo B, and interleukin-6 serum levels and a significant increased concentration of hemoglobin, hematocrit, erythrocyte count, iron, transferrin saturation, Apo A/Apo B ratio, adiponectin, and paraoxonase 1 serum levels. After adjustment for age these results remained significant. Our data suggest that higher bilirubin levels are associated with beneficial effects in HD patients, by improving lipid profile and reducing the inflammatory grade, which might contribute to increase in iron availability. These results suggest a potential cardiovascular risk protection of bilirubin in HD patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9