Adiponectin and markers of metabolic syndrome in obese children and adolescents: impact of 8-mo regular physical exercise program

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Henrique Nascimento (Author) Other; Elisio Costa (Author) FFUP; Susana Rocha (Author) Other; Clarice Lucena (Author) Other; Petronila Rocha Pereira (Author) Other; Carla Rego (Author) Other; Helena Ferreira Mansilha (Author) Other; Alexandre Quintanilha (Author) Other; Luisa Aires (Author) Other; Jorge Mota (Author) Other; Alice Santos Silva (Author) FFUP; Luis Belo (Author) FFUP

Journal

Title: Pediatric Research

Vol. 76 No. 4

Pages: 159-165

ISSN: 0031-3998

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 22 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-009-MR0

DOI: 10.1038/pr.2014.73

Abstract (EN): BACKGROUND: Adiponectin circulates as low-, medium-, and high-molecular-weight multimers (LMW, MMW, and HMW) and influences lipid profile and insulin resistance (IR), HMW being considered as the most biologically active form. We aimed to study the relation between adiponectin and markers of metabolic syndrome (MS) in pediatric obesity, and the impact of physical exercise. METHODS: The study consisted of a cross-sectional part and an 8-mo physical exercise program. Lipid profile, insulin, glucose, C-reactive protein (CRP), total adiponectin (TA), and homeostasis model assessment IR (HOMA-IR) were measured. Adiponectin multimers were studied in a prepubertal group. RESULTS: Obesity is associated with increased dyslipidemia, IR, and inflammation. TA is correlated inversely with adiposity, triglycerides, HOMA-IR, and CRP, and positively with high-density lipoprotein cholesterol (HDLc)/total cholesterol (TC) ratio. HMW mimicked TA associations. The intervention program led to a reduction of TC, low-density lipoprotein cholesterol (LDLc), insulin, HOMA-IR, and trunk percentage of fat, and an increase of HDLc/TC ratio, in the obese group. BMI improvements prevented adiponectin reduction and correlated with increments in HMW and MMW. CONCLUSION: Obesity-related increase in MS features might be linked to lower adiponectin. HMW and MMW were the multimers that most explained the MS features. The intervention program improved the lipid profile and IR, and prevented the reduction of adiponectin.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7