Electrochemical behaviour of sertraline at a hanging mercury drop electrode and its determination in pharmaceutical products

• Type: Article in International Scientific Journal
• Date: 2001

Authors

Vela, MH (Author) Other; Garcia, MBQ (Author) FFUP; Montenegro, MCBSM (Author) FFUP

Journal

Title: Fresenius' Journal of Analytical Chemistry

Vol. 369

Pages: 563-566

ISSN: 0937-0633

Publisher: Springer

Indexing

ISI Web of Knowledge - 28 Citations

Scopus - 31 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-000-VXP

DOI: 10.1007/s002160000686

Abstract (EN): The electrochemical behaviour of sertraline at a hanging mercury drop electrode (HMDE) was described. Different voltammetric techniques, such as cyclic, linear sweep, differential pulse and square wave voltammetry, were used. Voltammograms were obtained at different pH values with a Britton-Robinson buffer solution used as supporting electrolyte. The best results were found by square wave voltammetry with electrodeposition at alkaline pH using a berate buffer with a pH = 8.2 for the samples, containing 12% (v/v) methanol. Under optimised conditions, a linear relationship between 2.33 x 10(-7) and 3.15 x 10(-6) M of sertraline with a limit of detection of 1.98 x 10(-7) M was obtained. The electrochemical method developed was applied to the determination of sertraline in pharmaceutical formulations. Recoveries were close to 100%, thus proving efficacy of the proposed method for the quantification of sertraline in commercial samples.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4