Adiponectin is an independent predictor of tissue plasminogen activator levels in patients under haemodialysis

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Maria do Sameiro Faria (Author) Other; Sandra Ribeiro (Author) Other; Henrique Nascimento (Author) Other; Petronila Rocha Pereira (Author) Other; Vasco Miranda (Author) Other; Denisa Mendonca (Author) ICBAS; Alexandre Quintanilha (Author) ICBAS; Elisio Costa (Author) FFUP; Luis Belo (Author) FFUP; Alice Santos Silva (Author) FFUP

Journal

Title: Scandinavian Journal of Urology and Nephrology

Vol. 46

Pages: 461-465

ISSN: 0036-5599

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 1 Citation

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-002-2YX

DOI: 10.3109/00365599.2012.708943

Abstract (EN): Objective. The aim of this study was to evaluate the association of tissue-type plasminogen activator (t-PA) levels with clinical data of patients under haemodialysis (HD) and with several variables potentially related to endothelial function and dysfunction. Material and methods. In a cross-sectional study involving 189 Portuguese HD patients, circulating levels of t-PA, lipids, oxidized low-density lipoprotein (Ox-LDL), interleukin-6 (IL-6), C-reactive protein (CRP), adiponectin, plasminogen activator inhibitor type 1 (PAI-1) and fibrin fragment D-dimer were measured. Results. Considering the entire population, t-PA correlated inversely and significantly with adiponectin and high-density lipoprotein-cholesterol, and positively and significantly with age, body mass index, PAI-1, IL-6, CRP, D-dimer, cholesterol and Ox-LDL. In multiple linear regression analysis PAI-1, age and adiponectin remained statistically associated with t-PA values (p < 0.01 for all). The weakest significant association (p = 0.046) was that found between t-PA and D-dimer. Conclusion. Adiponectin is a main determinant of t-PA level, which may be a good marker of endothelial dysfunction in HD patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5