Biochemistry I
Keywords |
Classification |
Keyword |
OFICIAL |
Physical Sciences |
Instance: 2025/2026 - 1S 
Cycles of Study/Courses
Teaching Staff - Responsibilities
Teaching - Hours
Type |
Teacher |
Classes |
Hour |
Theoretical classes |
Totals |
1 |
1,00 |
André Moreira Neto da Silva |
|
0,428 |
Maria Adelina Coelho Ribeiro Costa |
|
1,071 |
Theoretical and practical |
Totals |
1 |
1,50 |
André Moreira Neto da Silva |
|
0,428 |
Maria Adelina Coelho Ribeiro Costa |
|
1,071 |
Laboratory Practice |
Totals |
4 |
8,00 |
Luís Manuel de Mira Vieira |
|
2,50 |
Maria Adelina Coelho Ribeiro Costa |
|
2,50 |
Maria Antónia Santos Mendes Salgado |
|
5,00 |
Teaching language
Portuguese
Objectives
1. To rationalize living systems in terms of basic Chemistry principles. To present Biological Chemistry as a mere subset of Chemistry.
2. To correlate knowledge from Organic and Inorganic Chemistry with Biological Chemistry.
3. To acquire specific knowledge about biological molecules and the cellular chemical organization.
4. Aspects of the specific Biological Chemistry of saliva.
5. To acquire some practical skills on chemical, biochemical and spectroscopic laboratorial methods.
Learning outcomes and competences
1. Knowledge of the biologically important carbon compounds reactions and their mechanisms.
2. Structural knowledge of the most important types of biological molecules.
3. Understanding of the importance of molecular recognition, intermolecular interaction and the hydrophobic effect in biological chemistry.
4. Ability to explain the function and action mechanism of biological compounds based on its molecular structure and reactivity, namely enzymes' catalysis, kinetics and regulation.
5. Understanding of the main metabolism global organization, namely the integration of anabolism and catabolism made by NAD (and FAD) and ATP (and other NTPs).
Working method
Presencial
Program
THEORETICAL AND THEORETICAL-PRACTICAL CLASSES
1. Elements of General Chemistry: acid/base equilibrium, pH buffers; solubility equilibrium.
2. Organic Chemistry elements.
3. Structure and function of biological molecules: carbohidrates, lipids, proteins, nucleic acids; kinetic and thermodynamic stability; intermolecular bonding and molecular recognition.
4. Enzymes: catalysis, selectivity, kinetics (Michaelis-Menten) and regulation.
5. Aspects of oral biological chemistry: organic/inorganic composition of saliva; functions of the different components.
6. UV/VIS spectrophotometry; Interpretation and treatment of experimental data.
LABORATORIAL CLASSES
Preparation and spectrophotometric dosing of solutions.
Potentiometric carbonate titration.
Sugar identification reactions.
Biological pigments: qualitative analysis by UV-Vis.
Kinetics of enzymatic hydrolysis of sucrose.
Denaturation and spectrophotometric analysis of DNA.
Mandatory literature
T.W. Graham Solomons and Craig B. Fryhle; Organic Chemistry, John Wiley & Son, Inc, 10th Edition., 2011
Nelson , David L.;
Lehninger Principles of Biochemistry. ISBN: 978-0-7167-7108-1
K. Peter, C, Vollhardt, Neil E. Schore; Organic Chemistry Structure and Function, W. H. Freeman and Company, New York, 4th Edition., 2003
Complementary Bibliography
José Antonio Ramos Atance,;
Bioquímica bucodental. ISBN: 84-7738-350-2
Teaching methods and learning activities
Theoretical classes consist of oral and PowerPoint presentation of the different programmatic topics, with continuous interaction with the students.
Theoretical-practical classes for the elaboration of exercises related to the syllabus of the course.
Practical classes involving laboratory experiments.
Evaluation Type
Distributed evaluation with final exam
Assessment Components
Designation |
Weight (%) |
Exame |
100,00 |
Total: |
100,00 |
Amount of time allocated to each course unit
Designation |
Time (hours) |
Estudo autónomo |
58,00 |
Frequência das aulas |
57,00 |
Trabalho laboratorial |
20,00 |
Total: |
135,00 |
Eligibility for exams
According to the General Regulation of the University of Porto Learners Assessment is considered a student fulfills the attendance to a course if, having been regularly enrolled, does not exceed the number limit faults corresponding to 25% of the foreseen classes, as regulated in the existing organizational unit.
Calculation formula of final grade
Denomination of assessments (all graded at 20 points):
A1 (1st frequency taken in Intermediate Assessment 1),
A2 (2nd frequency taken in Normal season),
EN (overall exam taken in Ordinary period)
ER (overall exam taken in Appeal period).
Options for approval, Final grade, F ≥ 9.50 values:
(1) F = 0.5 x A1 + 0.5 x A2
(2) F = EN
(2) F = ER
A2 and EN assessments are simultaneous and thus mutually exclusive. It is possible to switch from option (1) to options (2) or (3) but this means permanently discarding the mark obtained in A1.
Examinations or Special Assignments
Special assessment (TE, DA, ...)
The exam will consist of the same test that is taken by students taking the final exam or the appeal exam.
Classification improvement
In accordance with the rules of the University of Porto Regulations.
The exam will consist of the same test that is taken by students taking the final exam or the appeal exam.