Molecular and Cell Biology II

Code:

MD1203

Acronym:

BCM II

Keywords
Classification	Keyword
OFICIAL	Biology

Instance: 2010/2011 - 2S

Active?	Yes
Web Page:	http://moodle.up.pt/course/view.php?id=1005
Responsible unit:	Mestrado Integrado
Course/CS Responsible:	Integrated Master in Dental Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMD	122	PLANO OFICIAL 2007/2008 BOLONHA	1	-	6	90	162

Teaching language

Portuguese

Objectives

In this course we hope to provide the student with a solid knowledge about the cell molecular biology and organization, while encouraging literature research, discussion and collaboration between students in their learning process.

The student must acquire theoretical knowledge in the following areas:
- Cell membrane Structure
- Sorting and intracellular protein traffic
- Cell Communication
- Cytoskeleton and extracellular matrix
- Cell cycle and programmed cell death
- Mechanisms of cell division
- Developmental biology

The student must develop laboratory work skills , as well as the preparation of scientific reports.

Program

Membrane structure
The Lipid Bilayer and membrane proteins.
Membrane transport.
The Electrical properties of membranes.
The nucleus
Transport of molecules between the nucleus and the cytosol.
Protein transport to the mitochondria.
Peroxisomes and ER.
Intracellular vesicular traffic
Transport from the ER though the Golgi apparatus.
Transport to the lysosomes.
Endocytosis and Exocytosis
The Cytoskeleton
Cellular shape and mobility
Molecular motors
Extracellular matrix
Cell Communication.
General principles of cell communication
Cell signaling.
Cell cycle and mitosis
Stem cells, cell differentiation, cell proliferation control, apoptosis and cancer.
Meiosis and fertilization.
Developmental Biology
Biological models to study developmental biology
Segmentation and gastrulation in Xenopus Laevis
Genetic regulation and embryonic axis formation in Drosophila melanogaster.

Practical applications of DNA technology
PCR analysis of human DNA
Molecular diagnosis of human disease
Nucleus and chromatin
organelles and cellular components
Cell cycle analysis
Meiosis and germ cells
Developmental biology: drosophila

Complementary Learning:

Science case studies and preparation of an integrated seminar (with Biochemistry II and Epidemiology and Biostatistics II ) to present in the end of the semester:


Case study 1 : Osmosis is Serious Business! by Troy R. Nash
Department of Biology, Presbyterian College

Case study 2: Agony and Ecstasy - A Case Study on Cell Membrane Structure and Function
by Norris Armstrong, Biology Department, University of Georgia

Case study 3: Colon cancer A Case of Genetic Bad Luck?
by Anne M. Casper, Department of Molecular Genetics and Microbiology
Duke University



Integrative project themes (to be developed by students)
-Hyperthyroidism
- Autism
- Epilepsy
- Beriberi
- Osteoporosis
- Oxidative Stress
- von Gierke's Disease
- Trisomy 21
- Aphthous ulcer
- Oral cancer (squamous-cell)
- Hypertrichosis
- Lupus
- Sudden death
- Circadian Clock
- Prader Willi
- Phenylketonuria
- Gout
- Retinitis pigmentosa
- Hemophilia
- Duodenal ulcer
- Tetanus

Mandatory literature

Alberts Bruce 070; Essential Cell Biology. ISBN: 978-0-8153-4129-1
Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter; Molecular Biology of the Cell, 5th edition, Garland Science, 2007. ISBN: 978-0-8153-4106-2
Cooper Geoffrey M.; The^cell. ISBN: 0-87893-220-7

Complementary Bibliography

Steven R Goodman; Medical Cell Biology, Academic Press, 2008
Lodish Harvey 070; Molecular cell biology. ISBN: 0-7167-4366-3
Alberts Bruce 070; Molecular biology of the cell. ISBN: 0-8153-4072-9
Azevedo, Carlos; Biologia celular. ISBN: 972-9018-55-3

Teaching methods and learning activities

Active learning
case study discussions
integrative learning

Software

Moodle

keywords

Natural sciences > Biological sciences > Biology > Human biology
Natural sciences > Biological sciences > Biology > Molecular biology
Natural sciences > Biological sciences > Biology > Cell biology
Natural sciences > Biological sciences > Biology > Clinical biology

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Attendance (estimated)	Participação presencial	88,00
	Teste
	Exame
	Defesa pública de dissertação, de relatório de projeto ou estágio, ou de tese
	Trabalho laboratorial
	Teste
	Trabalho escrito
	Exame
	Total:	-	0,00

Eligibility for exams

Students must attend at least 75% of all classes to be admitted to exams.

Students who fail their exams are not obliged to attend classes the following year

Calculation formula of final grade

Theory (T) and Continuous evaluation (C) : laboratory and seminar presentation

Theory: 1 test (two hours)
Continuous evaluation: Laboratory work and reports, problem resolution and
Integrative seminar presentation

The final mark is calculated as follows:
Theory test (T) (maximum score 9/20) + Laboratory (maximum score 6/20) + Seminar presentation (maximum score 3/20) + class attendance (maximum score 2/20)

The student needs to score at least 9/20 as a minimal grade in each component (Theory and Continuous evaluation).

Students who fail continuous assessment may request a final global exam

Gobal exam final mark* : Theory exam (maximum score 12/20) + Lab Exam (maximum score 6/20) + class attendance (maximum score 2/20)

The student must attend at least 75% of all classes and have a final mark of at least 10/20 to pass the course

* See Comments

Special assessment (TE, DA, ...)

These students will be alowed to have alternative exam dates, in accordance with the law.

Final mark is obtained as follows:

Theory exam (maximum score 13/20) + Lab Exam (maximum score 7/20)

Classification improvement

It is obligatory to evaluate theory and laboratory components of the discipline.
Final mark is obtained as follows:

Theory exam (maximum score 3/20) + Lab Exam (maximum score 7/20)

Observations

* Students who failed the theory test but scored 14/20 or higher in their Continuous evaluation (Laboratory + Seminar presentation) are excused from the Lab exam. In this case final mark is calculated as follows:

Theory exam (maximum score 9/20) + Continuous evaluation (maximum score 9/20) + class attendance (maximum score 2/20)

Hours for Students:
Tuesdays 8:00 - 12:00h
Thursdays 9:00 - 13:00h
Fridays 10:00 - 12:00h