Molecular and Cell Biology II

Code:

MD1203

Acronym:

BCM II

Keywords
Classification	Keyword
OFICIAL	Biology

Instance: 2009/2010 - 2S

Active?	Yes
Web Page:	http://moodle.up.pt/course/view.php?id=1005
Responsible unit:	Mestrado Integrado
Course/CS Responsible:	Integrated Master in Dental Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMD	119	PLANO OFICIAL 2007/2008 BOLONHA	1	-	6	90	162

Teaching language

Portuguese

Objectives

In this course we hope to provide the student with a solid knowleadge about the cell molecular biology and organization, while encouraging literature research, discussion and collaboration between students in their learning process.

Program

Membrane structure: The Lipid Bilayer and membrane proteins. Membrane transport. The Electrical properties of membranes.
The nucleus: transport of molecules between the nucleus and the cytosol. Protein transport to the mitochondria. Peroxisomes and ER.
Intracellular vesicular traffic: transport from the ER though the Golgi apparatus. TRansport to the lysosomes. Endocytosis and Exocytosis
The Cytoskeleton. Cellular shape and mobility. Molecular motors.
Extracellular matrix.
Cell Communication. general principles of cell communication. Cell signalling.
Cell cycle and mitosis. Cell proliferation control, apoptosis and cancer.
Meiosis and fertilization.
Developmental Biology: biological models to study developmental biology. Segmentation and gastrulation in Xenopus Laevis. Genetic regulation andembryonic axis formation in Drosophila melanogaster.

Practical applications of DNA thechnology:
Molecular diagnostics
Protein analysis: experimental questions
Nucleus and chromatin
organelles
Cell cycle analysis
Meiosis
Developmental biology:drosophila

Complementary Learning:

Discussion of a scientific papers, science case studies and preparation of an integrated seminar (with Biochemistry II and Epidemiology and Biostatistics II ) to present in the end of the semester:

Articles to discuss in class:

Drugs and addiction, ecstasy and cannabis
Role of stem cells in cancer therapy and cancer stem cells: a review

Case study :

-The Physiology of a Neurodegenerative Disease: Huntington’s Disease
by Christine M. Fleet, Biology Department Emory and Henry College, Emory, VA

-Sometimes it is All in the Genes
by Anne Galbraith and David Howard, Department of Biology
University of Wisconsin—La Crosse

-Colon cancer A Case of Genetic Bad Luck?
by Anne M. Casper, Department of Molecular Genetics and Microbiology
Duke University

- But I’m Too Young!A Case Study of Ovarian Cancer
by Nancy A. Rice, Department of Biology, Western Kentucky University, and
Bruno Borsari, Biology Department, Winona State University



Some examples of Integrative project themes (to be developed by students)

Albinism
Alcoholism
Asthma
Atherosclerosis
Botox and Botulism
Cancer and Diet
Cancer and Solar radiation
Diabetes (Type I )
Diabetes (Type II )
Gastritis and Helicobacter Pylori
Gaucher’s Disease
Hepatic steatosis
Hepatitis B
HIV

Mandatory literature

Alberts Bruce 070; Molecular biology of the cell. ISBN: 0-8153-4072-9
Cooper Geoffrey M.; The^cell. ISBN: 0-87893-220-7
Steven R Goodman; Medical Cell Biology, Academic Press, 2008

Complementary Bibliography

Lodish Harvey 070; Molecular cell biology. ISBN: 0-7167-4366-3
Azevedo, Carlos; Biologia celular. ISBN: 972-9018-55-3

Teaching methods and learning activities

Active learning
case study discussions
integrative learning

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Attendance (estimated)	Participação presencial	0,00
	Total:	-	0,00

Eligibility for exams

Theory(T) and Continuous evaluation (C) : laboratory and complementary learning

Theory : 2 tests (one hour each)
Continuous evaluation : Laboratory work and reports, problem resolution, paper discussions
Integrative seminars


The student needs to score at least 7/20 as a minimal grade in each component (Theory and Continuous evaluation).

The student must atttend at least 75% of all classes and have a final mark of at least 10/20 to pass the course

Students who fail continuous assessment will have a final global exam

Calculation formula of final grade

The Final grade is calculated using the following values:

Theory tests (T) (maximum score 9/20) + Laboratory (maximum score 5/20) + Complementary learming (maximum score 4/20) + class attendance (maximum score 2/20)

Examinations or Special Assignments

Research monograph of the integrative project theme (optional)

Special assessment (TE, DA, ...)

These students will be alowed to have alternative exam dates, in accordance with the law.

Classification improvement

It is obligatory to evaluate theory and laboratory components of the discipline.