Molecular and Cell Biology II

Code:

MD1203

Acronym:

BCM II

Keywords
Classification	Keyword
OFICIAL	Biology

Instance: 2008/2009 - 2S

Active?	Yes
Course/CS Responsible:	Integrated Master in Dental Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMD	117	PLANO OFICIAL 2007/2008 BOLONHA	1	-	6	90	162

Teaching language

Portuguese

Objectives

In this course we hope to provide the student with a solid knowleadge about the cell molecular biology and organization, while encouraging literature research, discussion and collaboration between students in their learning process.

Program

Membrane structure: The Lipid Bilayer and membrane proteins. Membrane transport. The Electrical properties of membranes.
The nucleus: transport of molecules between the nucleus and the cytosol. Protein transport to the mitochondria. Peroxisomes and ER.
Intracellular vesicular traffic: transport from the ER though the Golgi apparatus. TRansport to the lysosomes. Endocytosis and Exocytosis
The Cytoskeleton. Cellular shape and mobility. Molecular motors.
Extracellular matrix.
Cell Communication. general principles of cell communication. Cell signalling.
Cell cycle and mitosis. Cell proliferation control, apoptosis and cancer.
Meiosis and fertilization.
Developmental Biology: biological models to study developmental biology. Segmentation and gastrulation in Xenopus Laevis. Genetic regulation andembryonic axis formation in Drosophila melanogaster.

Practical applications of DNA technology:
Molecular diagnostics
Interpretation of experimental results
Analysis of human and bacterial DNA by PCR
organelles
Cell cycle analysis
Meiosis
Developmental biology:drosophila

Complementary Learning:

Discussion of a scientific papers, science case studies and preparation of an integrated seminar (with Biochemistry II and Epidemiology and Biostatistics II ) to present in the end of the semester:

Articles to discuss in class:

Drugs and addiction, ecstasy and cannabis
"Botulinum Toxin as a Biological Weapon"


Case study :

-Cystic Fibrosis
-Colon cancer A Case of Genetic Bad Luck?



Some examples of Integrative project themes (to be developed by students)

Albinism
Alcoholism
Asthma
Atherosclerosis
Botox and Botulism
Cancer and Diet
Cancer and Solar radiation
Diabetes (Type I )
Diabetes (Type II )
Gastritis and Helicobacter Pylori
Gaucher’s Disease
Hepatic steatosis
Hepatitis B
HIV

Mandatory literature

Alberts Bruce 070; Molecular biology of the cell. ISBN: 0-8153-4072-9
Steven R Goodman; Medical Cell Biology, Academic Press, 2008
Cooper Geoffrey M.; The^cell. ISBN: 0-87893-220-7

Complementary Bibliography

Lodish Harvey 070; Molecular cell biology. ISBN: 0-7167-4366-3
Azevedo, Carlos; Biologia celular. ISBN: 972-9018-55-3

Teaching methods and learning activities

Active learning
case study discussions
integrative learning

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Attendance (estimated)	Participação presencial	82,50
	Total:	-	0,00

Eligibility for exams

Theory(T) and Laboratory (L) and complementary learning (C)

Theory
2 tests containing 15 "short-answer" questions

Test nº 1 represents 40% of the theory grade
Test nº 2 represents 50% of the theory grade
The remaing 10% will depend on the studants presence and participation during theory classes

The minimum grade in theory has to be a score of at least 10/20
Laboratory (L)
Presence in class - 10% of the laboratory grade
Class participation - 5% of the laboratory grade
Lab work - 15% of the laboratory grade
Lab reports and resolution of problems will make 70% of the laboratory grade

The minimum grade in laboratory has to be a score of at least 10/20

Complementary Learning (C
Presence in class - 10% of the complementary learning grade
Case studies and paper discussions - 40% of the complementary learning grade
Integrative project - 50% of the complementary learning grade

Calculation formula of final grade

The Final grade is calculated using the following values:

Theory (T) – 45% of the final grade
Laboratory (L) – 27% of the final grade
Complementary Learning (C) – 18% of the final grade
Presence in class – 10% of the final grade

Examinations or Special Assignments

Research monograph of the integrative project theme (optional)

Special assessment (TE, DA, ...)

These students will be alowed to have alternative exam dates, in accordance with the law.

Classification improvement

It is obligatory to evaluate theory and laboratory components of the discipline.