Molecular and Cell Biology I

Code:

MD1102

Acronym:

BCM I

Keywords
Classification	Keyword
OFICIAL	Biology

Instance: 2007/2008 - 1S

Active?	Yes
Course/CS Responsible:	Integrated Master in Dental Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMD	106	PLANO OFICIAL 2007/2008 BOLONHA	1	-	6	90	162

Teaching language

Portuguese

Program

The Cell: concepts and evolution. Universal characteristics of the cells. Eukaryotic and procaryotic cells. Celular Chemical components.

DNA: estructure and function. Genes and chromosomes. The Human Genome: Principal findings and future perspectives for medical practice.
DNA Replication,mutation and repair. General Recombination and site-specific recombination. Mobile genetic elements and evolution. Structure and organization of Víruses.

RNA: Structure and function. rRNA, tRNA and mRNA . The RNA world and the origin of life.

From RNA to Protein: Translation. Protein structure and function. Gene expression and mechanisms of control. Molecular genetic mechanisms that create specialized cell types .

Cell study methods: Isolating cells and growing them in culture. Microscopy. Molecular Biology thecniques and its application in medicine. Studying gene expression and function. Biological models of study in biomedicine.

laboratory/practical classes:

Lab safety rules
Learning how to use an optical microscope
Preparing samples for microscopy
DNA extraction
DNA amplification, PCR
DNA electrophoresis
Plasmid construction and restriction maps
Western blotting

Complementary learning:

Analysis and discussion of the following articles:

- “Where do genes come from? the case of the "green" parasites”
- “Genes, learning, behaviour and the outside world”
- “Faith and the Human Genome”
- “Superbugs – the problem of antimicrobial resistance”
- “1918 Influenza: the Mother of All Pandemics”
- “Prions: A scientific revolution?”
- “HIV and AIDS: 20 years of science”
- “Public perceptions of transgenic animals”
- “Unlocking the potential of the human genome with RNA interference”
- “DNA microarrays in clinical practice: past, present, and future
- “Why flies are relevant to medical research”
- “Animal Models for Human Diseases: Is There a Future Without Them?”

Mandatory literature

Alberts Bruce 070; Molecular biology of the cell. ISBN: 0-8153-4072-9

Complementary Bibliography

Cooper Geoffrey M.; The^cell. ISBN: 0-87893-220-7
Lodish Harvey 070; Molecular cell biology. ISBN: 0-7167-4366-3

Teaching methods and learning activities

Active learning

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Subject Classes	Participação presencial	110,00
	Total:	-	0,00

Eligibility for exams

Continuous evaluation, theory(T), laboratory (L) and complementary learning (C).

Theory (T)

Final Exam:

50 multiple choice questions (10)
7 short answer questions(7)
1 essay question (3 )

evaluation: 0-20

Laboratory/practical (L)

Lab experiments and reports (4)
Final Exam (16)

Evaluation:0-20

Complementary learning (C)

Paper discussons(0.5)
short questions concerning the papers discussed in class (1.5)

Evaluation: 0-2

Calculation formula of final grade

Formula:

{(3T+L)X18/80}+ C