Pharmacology

Code:

MD2402

Acronym:

F

Keywords
Classification	Keyword
OFICIAL	Clinical pharmacology

Instance: 2007/2008 - 2S

Active?	Yes
Course/CS Responsible:	Integrated Master in Dental Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMD	81	Plano de Transição 2º Ano Bolonha 2007	2	-	3,5	54	94,5

Teaching language

Portuguese

Program

I. General principles
1. Introduction to pharmacology
2. General concepts
3. Mechanisms of drug action
General principles
Molecular aspects
Cellular aspects
4. Pharmacokinetics
Passage of drugs across membranes
Absorption and distribution of drugs
Drug elimination
5. Individual variation to drug response
6. Harmful effects of drugs
7. Drug interactions
8. Biopharmaceuticals. Gene therapy
9. Method and measurement in pharmacology
10. Drug discovery and development
II. Chemical mediators
1. Autonomic nervous system
Physiology of cholinergic transmission
1.1 Drugs affecting cholinergic transmission
Drugs affecting muscarinic receptors
Drugs affecting autonomic ganglia
Neuromuscular-blocking drugs
Drugs that act presynaptically
Drugs that enhance cholinergic transmission
1.2 Drugs affecting adrenergic transmission
Physiology of noradrenergic transmission
Drugs acting on adrenoceptors
Drugs that affect noradrenergic neurons
2 - Inflammation and immune reactions
Inflammatory response
2.1- Non-steroidal anti-inflammatory drugs
2.2 - Drugs used in gout
2.3 - Antirheumatic drugs
2.4 - Antagonists of histamine
2.5 - Anticytokine drugs
2.6 - Immunosuppressant drugs
3 - 5-Hydroxytryptamine and purines
3.1 - Drugs acting on 5-HT receptors
3.2 - Drugs acting on purine receptors
4 - Peptides and proteins
4.1 - Peptides and proteins as drugs
4.2 – Peptides antagonists
5. Cannabinoids
6 - Nitric oxide
6.1 - Drugs affecting nitric oxide bioavailability
III. Central nervous system
Chemical transmission in the central nervous system
Targets for drug action
1 -Drugs used in neurodegenerative diseases
(Parkinson disease. Alzheimer disease. Huntington disease. Neurodegenerative prion diseases)
2 – Anxiolytic and hypnotic drugs
3 - Antidepressant drugs
4 - Antypsychotic drugs
5 - Antiepileptic drugs
6 - Central nervous system stimulants
7 -Analgesic drugs
7.1 - Opiate analgesics. Opioid antagonists
7.2 - Other analgesic drugs
8 - General anaesthetic agents
9 - Local anaesthetic agents. Other drugs affecting sodium channels
10 - Drug addiction

Bibliography
• Main bibliography:
“Rang and Dale´s Pharmacology”
Rang P, Dale MM, Ritter JM, Flower RJ. 6ª Edição. Churchill Livingstone 2007
“Pharmacology and Therapeutics for Dentistry”, 6ª edição. J.A. Yagiela, E.A. Neidle, F.J. Dowd. Mosby, 2005
• Complementary bibliography
“Farmacologia e Terapêutica em Medicina Dentária”
Maria Helena Fernandes. Medisa, 2006
"Terapêutica medicamentosa e suas bases farmacológicas", 4ª edição. Coordenação de S. Guimarães e P. Soares da Silva. Porto Editora, 2005.
Recent articles regarding the discussed subjects

Evaluation Type

Distributed evaluation with final exam