Melt Electrowritten Biodegradable Mesh Implants with Auxetic Designs for Pelvic Organ Prolapse Repair

• Type: Article in International Scientific Journal
• Date: 2025

Authors

Ferreira, NM (Author) Other; Antoniadi, E (Author) Other; Silva, AT (Author) Other; Silva, A (Author) FEUP; Parente, M (Author) Other; Fernandes, A (Author) Other; Silva, E (Author) Other

Journal

Title: Journal of Manufacturing and Materials Processing

Vol. 15

Final page: 111

Publisher: MDPI

Other information

Authenticus ID: P-018-EVZ

DOI: 10.3390/jmmp9040111

Abstract (EN): <jats:p>Pelvic organ prolapse (POP) is a common condition among women, characterized by the descent of pelvic organs through the vaginal canal. Although traditional synthetic meshes are widely utilized, they are associated with complications such as erosion, infection, and tissue rejection. This study explores the design and fabrication of biodegradable auxetic implants using polycaprolactone and melt electrowriting technology, with the goal of developing implants that closely replicate the mechanical behavior of vaginal tissue while minimizing implant-related complications. Four distinct auxetic mesh geometries¿re-entrant Evans, Lozenge grid, square grid, and three-star honeycomb¿were fabricated with a 160 ¿m diameter and mechanically evaluated through uniaxial tensile testing. The results indicate that the square grid and three-star honeycomb geometries exhibit hyperelastic-like behavior, closely mimicking the stress¿strain response of vaginal tissue. The re-entrant Evans geometry has been observed to exhibit excessive stiffness for applications related to POP, primarily due to material overlap. This geometry demonstrates stiffness that is approximately five times greater than that of the square grid or the three-star honeycomb configurations, which contributes to an increase in local rigidity. The unique auxetic properties of these structures prevent the bundling effect observed in synthetic meshes, promoting improved load distribution and minimizing the risk of tissue compression. Additionally, increasing the extrusion diameter has been identified as a promising strategy for further refining the biomechanical properties of these meshes. These findings lay a solid foundation for the development of next-generation biodegradable implants.</jats:p>

Language: English

Type (Professor's evaluation): Scientific