Is the Leptin/Adiponectin Ratio a Better Diagnostic Biomarker for Insulin Resistance than Leptin or Adiponectin Alone in Adolescents?

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Agostinis-Sobrinho, C (Author) Other; Vicente, S (Author) Other; Norkiene, S (Author) Other; Rauckien¿-Michaelsson, A (Author) Other; Kievisien¿, J (Author) Other; Dubey, V (Author) Other; Razbadauskas, A (Author) Other; Lopes, L (Author) FADEUP; Santos, R (Author) Other

Journal

Title: Children

Vol. VI Série

Final page: 1193

Other information

Authenticus ID: P-010-1J6

DOI: 10.3390/children9081193

Abstract (EN): <jats:p>Background: Recently, the leptin/adiponectin (L/A) ratio has been suggested as a novel predictor of cardio-metabolic and other chronic diseases. Aim: To evaluate the ability of leptin (L), adiponectin (A), and the L/A ratio in identifying high risk of insulin resistance IR in adolescents, adjusted by cardiorespiratory fitness, adherence to the Mediterranean diet, and body fat percentage. Subjects and methods: This is a cross-sectional analysis with 529 adolescents aged 12¿18 years-old. Blood samples were taken to analyze glucose, insulin, leptin, and adiponectin levels. IR (homeostasis model assessment of insulin resistance (HOMA-IR) was estimated from fasting serum insulin and glucose). Results: Adiponectin, leptin, and L/A ratio were accurate to predict IR among adolescents. The optimal L/A cut-off value to indicate risk of IR development was >0.35 in boys and >0.97 in girls. Logistic analyses showed that the suggested cut-off points for adiponectin (girls: OR: 2.87 (1.26¿6.53); p = 0.012); leptin (boys: OR: 5.23 (1.16¿7.14) p = 0.006; girls: OR: 2.99 (1.10¿8.09) p = 0.031), and the L/A ratio (boys: OR: 8.38 (2.6¿26.8) p < 0.001; girls: OR: 6.1 (2.1¿17.0) p < 0.001), were significant predictors of IR, after adjustments for age, pubertal stage, adherence to the Mediterranean diet, cardiorespiratory fitness, and body fat percentage. Conclusion: Leptin and L/A ratio were associated with IR risk, after adjustments for confounders in both sexes and adiponectin in girls. The L/A ratio seems to have a higher diagnostic accuracy to identify IR risk than adiponectin or leptin, in both sexes.</jats:p>

Language: English

Type (Professor's evaluation): Scientific