Antiulcerogenic activity of peptide concentrates obtained from hydrolysis of whey proteins by proteases from Cynara cardunculus

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Tavares, TG (Author) Other; Monteiro, KM (Author) Other; Possenti, A (Author) Other; Pintado, ME (Author) Other; Carvalho, JE (Author) Other; F. Xavier Malcata (Author) Other

Journal

Title: International Dairy Journal

Vol. 21 No. 3

Pages: 934-939

ISSN: 0958-6946

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 16 Citations

Other information

Authenticus ID: P-002-JFC

DOI: 10.1016/j.idairyj.2011.06.004

Abstract (EN): Peptide concentrates generated by hydrolysis of whey with aqueous extracts of flowers of Cynara cardunculus were studied for possible protection of the stomach mucosa against ulcerative lesions caused by oral administration of absolute ethanol. Both the whole peptide fraction obtained via hydrolysis of whey protein concentrate (peptide concentrate, PepC) and its fraction below 3 kDa (PepCF) were able to reduce gastric injuries to significant levels (p < 0.05). Single-dose experiments, using 100 mg kg(-1) body weight (bw) of either PepCF or PepC, led to 68.5% and 37.4% protection, respectively - which compare well with 93.4% protection by 200 mg kg (1) bw carbenoxolone (a positive control). No dose-response correlation could be demonstrated. Gastric cytoprotection by PepCF appears to depend on sulphydryl-containing moieties, whereas PepC likely protects the gastric mucosa via the prostaglandin cycle and production of nitric oxide. (c) 2011 Published by Elsevier Ltd.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6